Scientists have preserved brain tissue alive for weeks
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viability of the Central nervous system — the first step on the way to transplant the brain
With the development of transplantation scientists have started to find more and more opportunities for as long as possible to keep the tissue viable after removing them from the body. This is useful not only for organ transplantation but also for their study. This is the most «Moody» cloth remained the fabric of the Central nervous system that you should investigate, as a rule, «here and now». However, a group of scientists managed to develop a way to preserve the nervous tissue for several weeks. And this is a real breakthrough!
How to keep the brain alive for the transplant?
Unfortunately, transplant the brain it is not, but the discovery, in Japan, no doubt can help in the future if about transplanting neural tissue will begin to talk serious scientists and not . Although it is possible that the «scientist» more «shoots» we very much doubt. But if this happens — we will immediately notify you .
But back to the invention of the Japanese: the new system uses a microfluidic device that can keep the tissue from drying out, and from the accumulation in it of the liquid, because the tissue of the body is very well permeable for different solutions. That is why «just put» the tissue in a nutrient medium will not work. On the other hand, the lack of the nutrient medium will cause the tissue to die, not only from a lack of nutrients, but also from «drying» and the lack of gas exchange between the tissues.
To solve this problem, RIKEN scientists have developed a device using polydimethylsiloxane (PDMS), a material frequently used as a defoamer in various drugs. The new device has a semipermeable channel, surrounded by an artificial membrane and the solid walls of the PDMS. Instead of always immersed in the liquid, the fabric «won» from the fact that the nutrient medium circulating within the system and passed through a permeable membrane that allow for proper gas exchange. It sounds simple but to find the optimal conditions turned out to be extremely easy.
Control over the environment was difficult because the microchannel formed between PDMS walls and the porous membrane has a non-standard physical properties. However, we were successful after much trial and error. — said the lead author of the robots of Dr. Nobutoshi OTA.
Maintaining the viability of nerve tissue in a long time
The Team tested the device using tissue suprachiasmatic nucleus of the mouse brain, a complex part of the CNS that controls circadian rhythms. During a series of experiments, managed to keep the tissue active and functional for more than 25 days. The core still had a good circadian activity. However, in parallel, as a control, were the same area of the brain, but stored in a usual environment. It decreased by 6% after 10 hours, and later the cloth and ceased to perform its function.
According to the authors, the new method will have several advantages. In the short term it will be useful for monitoring the biological development and testing of CNS tissues react to the drugs. Long-term benefits are also obvious — transplantation. And the team of experts currently plans to develop both of these areas.
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