Scientists have created a "patch" for the intestines
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Cuts, tears, abrasion and other damage to the outer skin is pretty easy to fix. If the damage is serious — should be stitches. In most cases, you can restrict. But with the internal organs, this approach does not work. Although sometimes there are minor injuries not requiring major surgery. For these purposes, a group of researchers from the United States have created «patch», which you can treat wounds in the intestines.
Why «patch» for the intestines?
First and foremost, of course, it will help with the disease called «duodenal ulcer.». After all, the open ulcer regularly subjected to mechanical and physical effects and heals very poorly, enveloping and drugs are very long. Just as is the case with erosions and other damage to the walls of the intestine. In addition, we cannot rule out the use of the material in the healing of joints after surgery («sealing» them from the inside) and so on.
What is «patch» gut
In fact, the word «patch» quoted not just. Similar there is not so much the principle of use (measured-cut-pasted), but the essence of the work itself (closing the wound to further heal). In itself, the invention is a mixture of probiotic hydrogels made from mucoadhesive nanofibers. Sounds complicated? All really quite simple: hydrogels based on mucoadhesive nanofibers allow substances «mate» with the surface of the intestine. And the word «probiotic» means that the substances promote growth and development «useful» microflora.
This is absolutely new and unique new type designed of live material, — said one of the inventors Dr. Neil Joshi from the University of veys. Moreover, it does not require special storage conditions. A lot of conditions are suitable for the storage of conventional drugs.
How to create «patch of intestine
According to scientists, to create the material they use genmodificirebuli non-pathogenic strains of E. coli bacteria to obtain hydrogels. These hydrogels have a viscosity strongly reminiscent of the viscosity of mucus in the gastrointestinal tract (GIT). Moreover, different parts of the gastrointestinal tract mucus viscosity is different, but the bacteria can be «programming» different to the hydrogel was affected by exactly where you need it.
See also: .
To enable the formation of hydrogels, the researchers programmed a non-pathogenic strain of the intestinal bacterium E. coli for the synthesis of variant protein CsgA curli. It is responsible for production of mucus.
Naturally produced biofilms is known to hinder the healing process of wounds, if not timely removed. We are essentially «hacked» one of the main mechanisms that allows «patches» to perform its primary function of wound healing. After completing the work they «self destruct» and do not interfere with the further process of regeneration.
Not without the stage of laboratory tests. With the introduction hydrogels laboratory rodents through the mouth, it was found that hydrogels capable of withstanding the aggressive environment of the stomach and reach the «the scene», saving up to 90% active substance. When it became known that if the hydrogels are live bacteria, it prolongs the period of their validity the production of new mucus. Therefore, adjusting the amount of bacteria that can . What bacteria — so it is above. And Vice versa.
Now scientists aim to conduct a series of tests on people. According to the authors of inventions, their development will help in treating a number of pathologies of the gastrointestinal tract. In particular, peptic ulcer disease of the duodenum.
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