Editor CRISPR genome was first used for the treatment of HIV

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2019-09-12 19:40:08

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Editor CRISPR genome was first used for the treatment of HIV

the Editor of the genome — it is a powerful tool that can help us defeat the incurable disease.

Editor of CRISPR genome is increasingly used in medicine to treat patients. We regularly soobshaet on our portal. So if you don't want to miss any news, subscribe to our . If previously there have only been a series of experiments in the laboratories or in the best case the experiments on animals, now scientists are using advances in CRISPR to help people. For example, recently, Chinese physicians have used CRISPR to edit immune cells of a patient suffering from . And this therapy was to some extent very successful.

As the editor of the genome will help to cure HIV

In order to help the person, doctors decided to use the CCR532 mutation. It is open for a long time. And this rare mutation does T-human cells (responsible for immunity) resistant to HIV infection. The patient of 33 years, participating in the experiment, in addition to diagnosed HIV was discovered and T-cell leukemia. This is a complicated process. So people had to be treated by radiation therapy, which kill most of the T cells. And since they are responsible for immunity, after receiving this treatment the patient can die very quickly due to the rapid distribution throughout the body of the immunodeficiency virus.

In the end, the researchers decided to combine treatment with : after irradiation, they have introduced the patient already edited using CRISPR his own cell, which was «introduced» the above CCR532 mutation. CRISPR-modified cells engraft in the body. Most interesting is that 19 months after the experiment, the cells with the mutation was still detected in the patient's body. Moreover, the mutation was transmitted and other blood cells, not only a new T-lymphocytes.

see also: .

However, the number of these cells was still insufficient to completely cure the patient from a dangerous virus. The percentage of «mutated» cells were only 17.8% at the beginning of the experiment and about 8% in 19 months after the first injection.

the Process of editing the genome looks like. Part of the gene is cut out and replaced

However, the authors believe that their study successfully. On the one hand — it is the longest to date, the monitoring of CRISPR-edited cells in the human body. On the other hand, scientists have proved that even the long-term presence in the body of the edited cells will not be additional damage to the body. And, importantly, on the background whether a patient has cancer, the new cells turned into cancer cells, what is most feared by scientists.

Moreover, in theory, if you increase the number of modified cells in the human body, we can achieve regression of the virus and possibly even complete cure. Now Chinese doctors are looking for ways to create populations of cells that could «survive» in the body much longer to «replace» all blood cells are new and thus try to cure the patient from dangerous diseases.

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