Scientists have developed an effective method of pain treatment

Talk about pain and its treatment methods

Each of us from time to time pain. We don't so often think about what it is and how many types of pain exists. It turns out that the main type of pain only two, they are known as nociceptive pain and neuropathic . But despite the knowledge and classification of pain, the effective treatment method to date, does not exist. This is especially true for chronic neuropathic pain. Recently a study was published, the results of which demonstrates a real breakthrough in the treatment of pain. The method used by scientists, is able to relieve pain without any side effects.

What is nociceptive pain?

Nociceptive or physiological pain is caused by activation of nociceptors the body — activity-sensitive fibers of peripheral and Central nervous system — harmful or potentially harmful stimuli. Activation of these receptors leads to action and dissemination to the Central nervous system and brain. The physiological type of pain is a normal reaction of the organism to potential harm and serves to protect against emerging threats. This pain can be worn acute or chronic, depending on the individual case and causes.

Scientists klassificeret physical pain on two subtypes — somatic and visceral pain. the Somatic physical the pain arises from the activation of pain receptors, which are located on the body surface or musculoskeletal tissue. This type of pain, typically localized in a certain area and is often worse during physical activity, but subsides during rest.

Visceral pain refers to pain that arises as a result of activation of pain receptors located in internal organs. This type of pain is usually described as a feeling of deep pressure, which is not localized in a certain part of the body.

What is neuropathic pain?

Neuropathic pain, unlike physical pain caused by damage involved in the propagation of electrical signals that send messages of pain from receptors to the brain. The main difference is the origin of the pain is not due to the reaction to physical damage. This type of pain is usually described as sharp, shooting pain that is often quite intense. There are different causes of nerve damage and, as a result of arising pain, including can be caused by certain infections, diabetes, or certain surgical procedures.

the Pain can manifest itself in different ways

What is psychogenic pain?

This is an unofficial term sometimes used to describe pain that is associated with some mental disorders. Talking about psychogenic pain, when a person suffers anxiety, depression or is experiencing severe stress, which can negatively affect the body in the future and even cause pain.

What is acute, chronic or breakthrough pain?

In addition to the physical and neuropathic pain, there is a method for classifying type of pain based on its duration. So, there are acute, chronic or breakthrough pain. Under sharp pain, the researchers mean a normal and temporary reaction of the body, warning the body about injury. Chronic pain is often defined as any pain in the body, which lasts for 12 weeks or more. Breakthrough pain refers to acute episodes of pain that occur while taking pain medications for the treatment of chronic pain.

How stem cells will help cure the pain?

Recently, scientists have developed the first method of pain treatment using the person who provides lasting relief of chronic pain in mishy. The result is achieved in one step and does not have any side effects. As the researchers write in a paper published in a scientific journal , if the treatment proves successful in humans, this could be a major breakthrough in the development of new non-opioid and non-addictive drugs. Recall that at present there are no effective treatments for pain, especially devastating neuropathic pain caused by nerve injury.

At the moment an effective method of treatment of pain does not exist

The study used human induced pluripotent stem cells (IPSC) derived from bone marrow, to create pain cells in the laboratory. IPSC — these are cells that can develop into different types of cells in the body at an early age and in the process of growth. During work scientists put into the spinal cord of mice suffering from neuropathic pain caused by damage or disease that affects the nervous system. As the study authors write, neurons contributed long-term pain relief without side effects.

Because researchers can choose where to place pain neurons, they can only work on those parts of the body that “feel” pain. The researchers noted that stem cells were taken from blood samples of adults. The next step scientists wouldconducting safety testing in rodents and pigs. For human studies, scientists will begin within the next five years.