Invented apparatus is able to maintain the vital functions of the liver for weeks outside the human body

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2020-01-17 18:40:09

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Invented apparatus is able to maintain the vital functions of the liver for weeks outside the human body

in This project, scientists will help save hundreds of lives.

According to the publication , the scientists were able to invent a machine that is able to support the work of the liver for weeks outside the human body. Moreover, in addition to the sustenance of the body, the machine allows you to repair , if it was previously damaged as a result of automobile accidents or other injuries that lead to organ transplant. The device mimics the functions of the human body that allows the liver to continue usual work. The researchers hope that in the future the invention can extend the viability and other organs, not just liver. The work of the team of scientists from ETH Zurich, University of Zurich and at the local hospital published in the journal .

Liver — it is vitally important gland of external secretion of the vertebrates and man. She plays a huge role in maintaining metabolism and helps to neutralize allergens, poisons, toxins, turning them into harmless, less toxic and easily assimilable compounds, provides a synthesis of hormones and the body's energy needs, the processes involved in hematopoiesis and the synthesis of cholesterol, etc. Considering all of the processes on which this working of the human body, to underestimate the importance of its preservation and recovery impossible.

the Device to restore the liver looks like this

The Team of researchers responsible for the creation of a special unit, involved in its development in 2015. As the scientists write in their work, the existing, approved technology to support their work up to 24 hours, and the procedure of hypothermia allowed to extend the time to 27 hours. And it's a very big change in the field of organ transplantation, which needs to be extracted, transported and implanted during a potentially long and complex operations.

As the device supports liver function?

Existing technology works through perfusion that supports open and active blood vessels of the liver through blood circulation and body temperature (at 37 degrees) or oxygen-rich liquid blood substitute. A team of researchers from Zurich saw an opportunity to take a simple perfusion and turn it into something more reliable "by developing perfusion machine, which simulates the basic functions of the body, which is crucial for liver health". It turns out that the hardware simulates the natural processes — after the liver is attached to the machine with special tubes, it circulates through the liver with oxygen-rich blood and removes old. Pumped blood then passes through the dialysis filter system, cleansing the liver.

Left damaged liver, on the right — fixed using perfusion organ

In the course of work on the study, scientists hooked up to the machine corrupted the ten that were previously deemed unsuitable for transplantation. Six of them were able to recover their full functionality. Although the transplant has yet to produce, all the six bodies are in excellent condition, what is the guarantee that the operation would be successful. Have a working prototype and preliminary results of a study — a very big step for transplantation. So, patients with various liver injuries, including liver disease and cancer, will be able to get a chance to recover, which in the past they could not be.

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