In the brain open a physiological process that has searched for more than 100 years
Source:
The hallmark of some neurodegenerative diseases like the Huntington's disease is the gradual death of nerve cells in the brain. Thus cells don't die visapro. First, they start to "disconnect" from each other, and then breaking the links between them are progressing. During this process, because of which this occurs has remained unclear for more than 100 years since the first descriptions of the disease. And now the veil of secrecy parted.
The Discovery managed to make scientists from the Medical school of the University of Pittsburgh. They are using animal models and lab-grown nerve cells, found out about the existence of a new physiological process called "negritos".
"Negritos — it is a process that has never been previously described and it can play a very important role in normal brain development, aging and neurodegenerative diseases." — said lead author Dr. Robert Friedlander.
It All started with the fact that one of the members of the laboratory of Dr. Friedlander Sergey Baranov noticed an interesting phenomenon in the nerve cells of a laboratory mouse.
"Their mitochondria are not working as they should on the periphery of the brain cells. Then when we looked at neurons in the spinal cord, we found the same phenomenon. Probably noticed it before, but we have identified the relationship."
The Researchers found that when the proteins in the mitochondria were damaged, and new proteins were not reported. This made them function less effective activated "enzyme death", and ultimately caused the death of neurons. Scientists have suggested that neuritis is a variant of the apoptosis (programmed death process of cells).
The researchers Then decided to see if neurites plays a role in the development of neurodegenerative diseases. Previous work in teams Dr. Friedlander showed that the Huntington's disease impaired transport chain protein. Now they were able to confirm this guess.
"it is likely that neurites that begins in nerve cells and is considered the norm, with the physiological course does not lead to cell death. But at higher level of stress to already vulnerable cells may develop neurodegenerative lesions, which leads to the first violation of the ties, and then neuronal death. If we find a way to protect the mitochondria, we find the key to treating disease."
The Best way to develop the brain — to learn something new. And for this perfect our news page in
Recommended
The coronavirus has mutated into 30 new strains
While coronavirus Apocalypse slowly but inevitably becomes routine, the virus SARS-CoV-2 continues to evolve. And, unfortunately, he was good at it. Writes , with reference to the South China Morning Post reports that new studies show that the virus ...
In the United States recognized that the ventilator dies 88% of patients with coronavirus
When the world is raging coronavirus that causes pneumonia and kills people, the only solution is intensive care. If this is not done, the victims will be very much. Today for severe patients there is only one solution — connected to the appara...
Can a transfusion of blood plasma to cure the coronavirus?
Typically, vaccination involves the introduction into the organism of the weakened or killed microorganisms (viruses) designed to create a strong immunity to possible future infectious diseases — that is, for selection of antibodies. But what i...
Related News
Blood cells turned into neurons. This will help in the treatment of diseases of the nervous system
in the early 21st century mass to obtain stem cells for research has been extremely problematic. Not to mention the development of new therapies. That all changed in the mid-noughties, when it was developed the method of "reprogra...
The algorithms of life and death: how to understand artificial intelligence that can heal people?
When it comes to machine learning, most often the conversations are about the medical field. This is not surprising: a huge industry that generates a phenomenal amount of data and revenue, in which technological advances can impro...
Developed a new method for the synthesis of superactivation
According to official statistics superbugs that are resistant to traditional methods of antibiotic therapy, are the cause of death of about 100,000 people around the world. And in order to resist the tiny killers you need a specia...
Created implant, which eliminates excess weight and overeating
Only according to official statistics, in the world there were more than 700 million people suffering from excess weight. Therefore, the question of dealing with it rather important. For various reasons the "traditional" methods o...
Found a way to teach the heart to heal itself
the Heart is one of the most important organs of our body, and given the increasingly disappointing growth statistics of cardiovascular diseases, the development of new treatments is extremely important. And recently a group of re...
Experimental HIV vaccine worked and has protected primates
For a very long time, scientists from all over the world trying to find a way to defeat the insidious HIV has already claimed many lives. A group of experts from the research center of Scripps Research () of the last 20 years deve...
Created electronic tablet with remote control
In the near future approach to the treatment of a variety of diseases can change dramatically due to the emergence of "e-pills". One such recently developed by researchers from Massachusetts Institute of Technology (MIT). Small ga...
CRISPR-children: the next giant leap for mankind
In late November, the MIT Technology Review told us an amazing story: the story of the birth of the first children who went through the edit genes being embryos. Then it became known that a miracle happened in a small Chinese hosp...
New spray gel will prevent the recurrence of cancer
depending on the type of cancer, patients will receive one or another form of treatment. But despite this, after all medical procedures, all people who have had cancer, have a pretty high chance of recurrence of this dangerous pro...
Scientists are ready to transplant pig skin man
Modern transplantation, unfortunately, is still not able to provide the required bodies to all those in need, so in this area conducted a variety of surveys in order for this limitation to be overcome. Many of you have probably he...
Russian scientists have developed a new more accurate method MRI of the brain
the Procedure magnetic resonance imaging (MRI) has long been an indispensable tool for diagnosing a variety of conditions. It is particularly useful when scanning of the brain. But very soon the MRI will be more accurate as a grou...
Discovered new communication of the intestine with the brain. Again, blame the salt
it is Well known that a diet high in salt leads to high blood pressure which is a risk factor for many health problems, including heart disease and stroke. But over the last decade, studies conducted among the population showed th...
From skin cells made of cells of the immune system. And it will help in the treatment of cancer
Scientists have long found a way to "reprogram" cells. If you try to explain complex scientific terms, in the process, from cells of one species can be to others that may be useful in a number of cases. For example, recently a gro...
Carried out successful transplantation of pig hearts to baboons
a Large group of scientists from several institutions in Germany, Sweden, Switzerland and the United States was transplanted into the hearts of pigs, baboons, and sustained life over a long period of time. In his article, publishe...
Opened a new location of the origin of blood cells in the human body
according to the publication, Cell Stem Cell, a team of researchers from the Columbia center for translational immunology a few years ago I noticed a very interesting pattern: many patients undergoing transplantation of the intest...
Video will help neurostimulation for epilepsy and protect from depression
Different processes in our brains, despite a rather good understanding of the physiology and anatomy of the body is still a mystery. In particular, it concerns a condition like epilepsy and various disorders psihoemotsyonalnoe sph...
Scientists for the first time in history raised artificial placenta
the Creation of artificial organs is not always relevant to the area of transplantation. Sometimes it is necessary to conduct various studies and even less serious research. For example, recently a team of scientists from Cambridg...
earlier this week, the whole world literally was shocked about the fact that in one of the hospitals of China were born the world's first children edited using CRISPR genome. This is a really important event for the international ...
Scientists have learned how to create a pill from obesity
Everyone knows that as a "safety stock" in our body has fat tissue. However, this same fabric we have as many as 2 types: the so-called white fat and brown fat. If the first — these are the fat that retain nutrients, the sec...
Scientists have invented an implant for nose people the sense of smell
Thanks to committed scientists and discoveries developed on their basis in medical technology today, deaf people have the opportunity to hear, and the blind to see. For compensation of hearing loss for many years used a cochlear i...
Comments (0)
This article has no comment, be the first!