Found a way to create an effective pain medication from the venom of rattlesnakes
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In one of our we mentioned that snake venom is widely used in the manufacture of drugs for the treatment of cardiovascular diseases and strengthening the immune system. However, scientists also know that the venom of South American rattlesnakes (Crotalus durissus terrificus) possesses strong analgesic properties and in theory can be used to treat cancer. About the same time, scientists know for more than ten years, but the creation of a strong analgesic always hampered by the fact that the poison remained too dangerous for people's lives. Fortunately, recently, Brazilian researchers have found a way of reducing toxicity that may be considered the first step towards the development of drugs based on the venom of rattlesnakes.
About the discovery of scientists was described in a scientific journal . The main active substance contained in the venom of rattlesnakes is the so-called crotoxin. Author of the research paper Giselle Piccolo is studying this matter from the distant 2011 and it has already long been convinced of its anti-inflammatory, painkillers and anti-cancer properties. But, as mentioned above, the establishment of the commercial drugs always prevented the danger of poison for the health of the body. To reduce the activity of toxic substances helped the study conducted by absolutely other scientists.
New drugs from snake venom
A Group of scientists headed by Professor Oswaldo Sant’Anna has long been engaged in the development of a vaccine, whose main goal is to activate an immune response of the body against potentially harmful substances. During one of the scientific papers the researchers found that if introduced into the animal organism dangerous antigens with particles of silicon dioxide, the mixture increases the amount of produced antibodies, which fight hazardous substances. Experiment on horses all have shown that silicon dioxide can reduce the force of potentially hazardous substances. On hearing this, Giselle Piccolo suggested that dioxide even can reduce the impact of snake venom.
Tests in animals have shown that a mixture of crotoxin and silicon dioxide is indeed less dangerous than entered separately. Moreover, the mixing of the two substances increased the duration of analgesic effect for up to 48 hours. Scientists explain the reduction of toxicity by the fact that particles of silicon dioxide prevent the splitting of crotoxin and even allow you to take the medicine in pill form.
At the moment the substance crotoxin can only be obtained from the venom of rattlesnakes
Unfortunately, despite the successful experiment to create a commercial based on snake venom is still far. First, scientists need to conduct tests on people, for which they need to obtain permission from the regulatory authorities. Secondly, at the moment, crotoxin can only be obtained from the venom of rattlesnakes, and you can get it in the laboratory, the researchers have not yet learned.
Anyway, the first step to a cure is already done and now the scientists, it is important to create a technology laboratory synthesis of toxic substances. According to Giselle Piccolo, crotoxin is a substance with an extremely complex structure and its production in the laboratory can take quite some time.
the Venom of rattlesnakes (Crotalus durissus terrificus) can be the base for new painkillers
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