Created substances that can initiate tissue regeneration
Source:the Authors of works on creation of the substance that triggers the regeneration of tissues. Stefan Engers (left) and Sachdev Sidhu (to the right)
Recovery ability of our body is very high. However, this is true only in the case if we are talking about minor damage. Those deep cuts after healing often overgrown , and rough scar tissue. Scientists around the world regularly searching for a way to improve the regenerative capabilities of the human body (especially in the animal world is full of such examples). And, it is possible that a group of researchers from Canada did it. If you are interested in this topic, then be sure to subscribe to our .
How to start the process of tissue regeneration
Surprisingly, his opening scientists have made in the process of working on the study of antibodies that the body produces to fight infections. This is not the first case in the world, when antibodies «turn» in medicines. This is due to their ability to bind proteins and influence thus on the work of living cells. Since the proteins encoded by certain genes, they can be easily created in the laboratory and protein engineering. As the researchers report, based on antibodies they managed to develop their «improved synthetic analogues».
We are in their studies, using antibodies, creating new molecules that do not exist in nature. But however their potential is just huge, — said one of the authors, Professor at the Centre for cellular and biomolecular research Donnelly, Sachdev Sidhu. Using available methods, we can create a substance that will transform the entire . And it would make them not so expensive.
A New substance has received the name FLAg. They are in essence analogs of Wnt proteins. The fact that the body proteins of the Wnt start the process of growth and development of stem cells into cells of any other species. Wnt very active in the formation of the embryo, but after birth the activity of these proteins is reduced. But why then just not «add» Wnt? Why create analogues?
Salamanders. Some of the most amazing creatures on the planet. They can easily grow lost limbs.
Actually, the Wnt in the adult organism is still present in small amounts and even performs its function. Only here protein this is so «powerful», which can cause uncontrolled cell growth, leading to the development of cancer. Therefore, it needed to create a substance that would perform the same function, but which could easily be adjusted. So there FLAg.
People for decades have tried «rein» Wnt proteins and make them of medication. The problem is that these proteins are arranged in such a way that they are difficult to manage. Moreover, lipids in the composition of the Wnt prevent the dissolution of proteins in water, making them unsuitable as medicines.
Of Course, scientists have conducted a series of experiments. When adding a FLAg in a cell culture, they behaved the same way as Wnt, stimulating the growth of cells. Thanks to more «fine tune» was able to stimulate the formation derived from stem cells balls of tissue that resemble the small intestine.
But that's not all. With the introduction of the FLAg in the gastrointestinal tract of laboratory mice, the animals activated the stem cells of the intestine, showing on the one hand the fact that antibodies are stable and functional within the body, and on the other that a simple introduction is enough to start the regeneration process. While scientists claim that they can develop other specific variants of the FLAg of the lungs, liver, bones and other tissues of our body.
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