Scientists have created a gel for wound healing of the intestine
Source:a New drug to protect the intestines and cure inflammatory diseases
Inflammatory bowel disease is one of the most common pathologies in our world. According to official statistics, several billion people have some bowel problems, including Crohn's disease, ulcerative colitis, inflammation of the duodenum, and so on. only in the United States in the year registered about 70,000 new cases of inflammatory bowel disease. However, to rectify the situation meant new means of gel that separates the problem area from the aggressive environment of the intestine, promoting tissue regeneration.
From which are formed the inflammatory bowel disease
The Exact cause of the most common diseases of this kind are still poorly understood, but it is believed that the leading role in this process plays a wrong immune system. Inflammatory lesions destroy epithelial cells that function as a barrier. This loss of barrier function leads to a kind of cycle: inflammation causes more destruction of the barrier, and the destruction of the barrier leads to progression of inflammation.
A New gel, created by scientists from Harvard University, helps maintain the barrier function of the intestines even in the presence of inflammatory lesions. Experiments on animals showed that the drug, like the patch, closes the wounds of the intestine and promotes healing of the mucous membrane. Thus, existing methods of treatment of such conditions is expensive and not always effective. For example, the standard today is the use of anti-inflammatory drugs and antibiotics that will fight off infections that are often «satellites» such lesions. But anti-inflammatory drugs can have serious side effects on the whole body, and the antibiotics able to destroy the existing , from which also depends the variety of functions — from digestion to the production of certain vitamins.
But the research team from Harvard University under the leadership of Dr Neil Joshi has developed a new approach. The gel is composed of a strain of genetically modified E. coli. Their uniqueness lies in the fact that they produce a network of nanofibers, which communicates directly with the intestinal mucus in order to fill out the inflamed areas, protecting them from intestinal microbes and aggressive factors of the intestinal environment.
Our approach «bacterial therapy» we have created a unique biomaterials, which are produced by special bacteria and sticks to the walls of the intestine, at the same time firmly sticking to and moving viscous layer of mucus. This is a challenging task. We call this method The Therapeutic Probiotic Associated Curli Hybrids (PATCH). – say the authors work.
from Left to right: healthy bowel tissue, bowel in the stage of inflammation and the bowel after the use of the new drug.
In order to create a unique gel, a team of scientists programmed a laboratory strain of E. coli for the synthesis and secretion of the modified protein CsgA. He has the desired properties, but the problem is, he starts to act only in the environment of the intestine. Therefore, it is necessary to develop a «on the spot». For this new drug and included a genetically modified strain of bacteria. About new technologies in the field of medicine and not only do we regularly reported on our website in Yandex.Zen. So .
In the course of research, we discovered that the bacteria even when such us through the mouth also inhabit and live in the intestinal tract, and the drug is extremely convenient for patients.
Scientists believe that their approach can be used as a collateral method of therapy. Which can be used in addition to existing anti-inflammatory and anti-bacterial methods and treatment regimens, which reduces the activity of the immune system (which, as mentioned, considered a leading factor in the development of inflammation). In this case additional protection of the intestinal gel has to be very helpful.
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