With antibiotics was able to block the ability of cancer cells to obtain energy
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According to the news Agency TASS, a group of researchers from Russia, Spain and the Czech Republic with antibiotics were able to block the mitochondria of cancer cells, as well as starting the process of inhibition of autophagy and self-healing cells. Thus cells can be deprived of food and destroy. Scientific work was recently published in the journal Cancer Letters.
Mitochondria are — it is a kind of «power plant» cells. They are responsible for oxidative processes and energy production. Autophagy same — it is a way to clean the cell of damaged organelles for subsequent regeneration. For the discovery of this process, a Japanese scientist, asinari Osumi received in 2016 the Nobel prize. Now scientists are looking for antibiotics which would affect the protein synthesis apparatus of mitochondria of cancer cells, but did not touch the healthy cells. One group of researchers says the facial recognition software on images of non-functional mitochondria to the effectiveness of antibiotics was determined by the robot. The other is looking for ways to fight cancer stem cells. Says researcher, Institute of molecular biology and Biophysics Alex Lyakhovich
«If we want not only to deprive the cancer cell of energy, which it is allowed to mitochondria, but also the ability to resist this deprivation should pick up connection, overwhelming the function of mitochondria of the cancer cells and simultaneously inhibit autophagy to the cell is not able to quickly recover non-functioning organelles and eventually died. Following the ideas of Dr. Michael Lisanti from the University of Manchester, we have shown the opportunity for simple models with antibiotics and inhibitors of autophagy».
Autophagy, essential for the survival of healthy cells is a major obstacle in the fight against neoplastic diseases. And since cancer cells have accelerated metabolism, many scientists now tend to believe that autophagy — a key moment in the survival of cancer cells after chemotherapy.
«Antibiotics kill good bacteria as well as mitochondria historically, bacteria have a lot in common, their functions are also suppressed. The mitochondria in a living cell are linked in the so-called reticulum — it looks like a string of sausages, which are enmeshed inside our cells. When the mitochondria «spoil», for example, under the influence of antibiotics, mitochondrial chain is broken, and the cell begins to receive less energy».
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