Forgetfulness depends on the time of day, researchers found
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the Reasons that you about something have forgotten, can be much more complicated than it seems at first glance.
Do you Consider yourself a forgetful person? Even if not, you will certainly be interested to know that according to a study published in the journal , the ability to remember and retrieve memories depends on the time of day. At least, that's how things are in laboratory mice. In their work, scientists describe discovered in rodents the gene that influences the degree of memory retrieval at different times of the day. The researchers found that this gene makes the most forgetful when they Wake up. Experts believe that perhaps closer to the answer to the question of what makes people forgetful.
Researchers have been trying to understand how the brain forms and retrieves . Today scientists know only that this is an incredibly complex process. From the point of view of neuropsychology forgetfulness is divided into two categories. The first may mean that you don't remember some information, as they did not remember and haven't studied it. For example, you can "forget" the name of the person you recently met. Another category of forgetfulness — is the inability to extract the necessary information from its location in the brain.
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The experiment involved healthy mice, and mice that lack the protein BMALI 1 — he is responsible for the expression of many genes, including those responsible for memories. In the study, researchers applied the test by which it could distinguish two categories of "forgetfulness" and studying the memories of young males and females. In the first phase — "learning" — scientists have allowed the rodents to explore a new object for several minutes. In the second stage — the "memorial" — the researchers observed how long the mouse has interacted with the object that was seen in the first stage. It turned out that at the second stage, the less rodents interacted with the object, as has already seen him and . The researchers then decided to test the memory of mice by showing them the object at different times of the day.
it Turned out that the mouse is the most forgetful after waking
It Turned out that evening, the mouse remembered the object, but in the morning there. Moreover, the researchers found that BMALI protein 1 in healthy mice is present in various concentrations depending on the time of day. So, his level is very low before the awakening of the animal, but increases during sleep. Thus, the time of day affects recovery and BMALI 1 may play a significant role in forgetfulness.
How are circadian rhythms and memories?
Today, scientists can “turn on” and “off” some genes in the laboratory
Previous studies have shown that circadian rhythms — natural with a period of about 24 hours, which play an important role in managing the sleep cycles and Wake — also closely related to the tasks of learning and forming new memories. The study provides evidence that circadian rhythms regulate memories. Protein BMAL 1 encodes genes involved in the recovery of memory in the hippocampus. Scientists believe that understanding how the protein BMAL 1 affects the genes that help to restore the memories of can help in the development of new drugs for the treatment of dementia and Alzheimer's disease.
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