Confirmed: a molecular "switch" will destroy cancer cells without complications
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The Cells in our body regularly die and are replaced by new ones. The mechanism of "planned" cell death is called apoptosis and is a completely normal physiological process. But what is typical for normal cells, the cancer cells. They simply lost this feature. But what if it would be possible to force tumour cells to 'remember' this mechanism? Researchers say it's possible. They even confirmed this in a series of experiments.
According to new research, micro-RNA can be used to send cancer cells "reports of destruction, which they cannot ignore." earlier this year, researchers from northwestern University (located in the suburbs of Chicago, in Evanston) describe the mechanism by which each cell in the body can be programmed for destruction. Now the same research team reported that they managed to finally crack «code» necessary to run this sequence, and even to confirm these findings in experiments.
As reported by the authors in their new study, the indication of death of cells sends ribonucleic acid (RNA) and specific micro-RNA. And the code itself consists of six nucleotides small interfering RNA (siRNA). Getting all six of these nucleotides in the cell causes irreversible changes, similar to those that occur when exposed to chemotherapy drugs. During laboratory tests on tumor cells revealed that code simultaneously destroys multiple genes essential for cells to survive, so cancer is not able to develop resistance. In addition, this approach almost does not affect healthy tissue, and therefore the number of complications will be minimal.
"Now that we know the "code killing", we can start the mechanism without resorting to chemotherapy. We can use these micro-RNAS directly to enter their cells and run the "switch" that causes destruction of tumors." — said lead author Professor Marcus Peter.
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