As a mathematician helped biologists to make important discoveries

Date:

2017-03-14 22:00:08

Views:

2772

Rating:

1Like 0Dislike

Share:

As a mathematician helped biologists to make important discoveries Source:

Despite the fact that mathematics often called the fundamental science, she often doesn't get enough respect when scientific discovery. But the contribution of mathematics and statistics is very important and transformed whole areas of research, many discoveries would not have been possible without them. Further — the story of mathematics from the first person.

As a mathematician, I have contributed to scientific discoveries and has provided solutions to the problems that tried to solve the biologists. Seven years ago, I attended a lecture on the subject of biological studies that were conducted at the University of Herio-Watt. My colleagues were unresolved problem associated with movement along with sacklike structures called vesicles, which move hormones and neurotransmitters such as insulin and serotonin on the cells and body.

Their problem was the fact that vesicles are known to follow certain tracks on the skeleton of the cell that lead to specific molecules, which then cause the vesicles to release their contents into the cell. However, when the biologists tried to find these tracks, those were not in the expected places.

It is Important to understand how to behave (or not behave) vesicles because they are associated with various diseases, from diabetes to neurological disorders. Biologists could not find a way of understanding these vesicles — but I had a solution in the mathematical Toolkit.

the

Math is better than biology?

After two years of working together, I told colleagues: "My model and computer experiments to better your microscope!".

By this rather proud statement I meant that using math to simulate the movement of molecules around the cell we can predict and conduct many experiments on the computer at scales smaller and more rapid pace than under the microscope. This allows us to reveal what we can't afford the resources biologists, and even point us in the direction of the target molecules for future treatment of diabetes and neurological disorders.

The Mathematical model allowed us to understand that the movement of vesicles requires energy — and math models it on the energy landscape. Suppose a vesicle — that of a cyclist riding a bike landscape can have a smooth and rough sections that require more energy to overcome them. We wanted to test whether vesicles are trying to avoid these hills.

After seven years of collaborative work with biologists, my colleagues proved that our hypothesis is correct. Vesicles do follow a low-energy "valleys", avoiding molecules that create energy bumps in the energy landscape, choose the easy way out. And the result is expected for biologists: vesicles are proving to be one of the final locations and again use the same path. The only difference was in how they do it, and they do this not just by following the cell skeleton was believed to biologists — they choose the simplest route. This discovery demonstrated the power of mathematics and its capabilities in other Sciences.

Mathematical models allow you to collect many gigabytes of raw data in a compact form, why can't biologists with microscopes. You can easily amend the model and see how can change the behaviour of the vesicles during illness, when damaged or mutated. It can also show which molecules to focus in future research and to lay the Foundation for larger, more thorough modelling of complex biological processes.

Modeled energy landscape

Integration of advanced microscopy cell biology and mathematical modeling can be applied to many other problems in Biomedicine and to accelerate the pace of future discoveries. The movement of molecules and other cellular components is just one example of what can mathematics, but it is, of course, is not limited.

The Math has often criticized the company for lack of "real" applications, but it applies to many real problems. Groundwater pollution, financial and economic forecasting, the height of the eruptions, modeling of biological processes and drug delivery are just a few examples. Mathematics plays a Central role in many scientific achievements of the world and deserves a leading role in most scientific publications.

Gabriel Lord, mathematics Professor at the University of Herio-Watt

Recommended

What will be the shelter for the first Martian colonists?

What will be the shelter for the first Martian colonists?

Mars is not the friendliest planet for humans While the Red Planet is roaming rovers, researchers are pondering the construction of shelters and materials needed by future Martian colonists. The authors of the new paper suggest that we could use one ...

New proof of string theory discovered

New proof of string theory discovered

Just a few years ago, it seemed that string theory was the new theory of everything. But today the string universe raises more questions than answers String theory is designed to combine all our knowledge of the Universe and explain it. When she appe...

What is the four-dimensional space?

What is the four-dimensional space?

Modeling camera motion in four-dimensional space. View the world in different dimensions changes the way we perceive everything around, including time and space. Think about the difference between two dimensions and three dimensions is easy, but what...

Comments (0)

This article has no comment, be the first!

Add comment

Related News

The more accurate the clock, the more blurred becomes the time

The more accurate the clock, the more blurred becomes the time

Time is a strange thing. We used to count the hours, but the Universe is not some main clocks and dials, so we can experience time differently, depending on how we move or how we are affected by gravity. Physicists have tried to u...

Humanity is one step closer to creating synthetic yeast

Humanity is one step closer to creating synthetic yeast

Scientists are one, but very significant step towards the creation in the laboratory of yeast. They were able to generate five chromosomes of yeast. Yeast is essential for humanity, including for the production of bread and bakery...

The clarification rate of the Universe may lead to new physics

The clarification rate of the Universe may lead to new physics

It was in the early 1990-ies. The Carnegie Observatory in Pasadena, California, was empty for the Christmas holidays. Wendy Freedman, one in the library worked on the huge and thorny problem: the rate of expansion of the Universe....

It has created a lighting system for lasers

It has created a lighting system for lasers

the Engineers of the holding "Ruselectronics" is launching a novel lighting system which is based on the use of laser radiation. These lights can operate in hostile environments like nuclear power stations and even underwater. Rad...

Breeder from the USA brought out Python print Emoji-Emoji on the body

Breeder from the USA brought out Python print Emoji-Emoji on the body

it is known that changes in nature occur constantly: mutations lead to new species and even species, and is influenced by conditions in the external environment living organisms can acquire new properties. But sometimes appeared a...

The operating system code recorded in the DNA molecule

The operating system code recorded in the DNA molecule

In connection with the development of technology and the increasing amount of data, professionals are looking for new ways of storing information. And recently a group of scientists from Columbia University and the new York Genome...

Created a sponge capable of cleaning the ocean from oil and oil products

Created a sponge capable of cleaning the ocean from oil and oil products

and its by-products today are the main oceans of our planet. Almost all serious cases of ocean pollution are associated with oil. Even if we ignore the serious accidents of tankers and oil platforms, you should not forget that th...

As was discovered the oldest fossils in the world

As was discovered the oldest fossils in the world

3770 million years ago the Earth was completely different. Plants and animals were not. The sky was not blue. The surface resembled a bare rocky wasteland. And yet at this time, as we think, came the first life. Deep in the ocean,...

Why do tall people die earlier and larger animals — no?

Why do tall people die earlier and larger animals — no?

the tallest man in Europe, 2,34-foot former basketball player, actor Neil Fingleton, who played the role in "Game of thrones", "X-Men" and "the Avengers", has died at the age of 36. Such an early death for people tall is not uncom...

Would agree on the genetic modification of the dog for the sake of her health?

Would agree on the genetic modification of the dog for the sake of her health?

dogs Have more genetic diseases than any other species on the planet — that you any biologist will confirm. Not gonna lie: no other animal people are not taken out so purposefully and long to form prevailed over substance — appear...

The merging of man and machine will not stop the rise of the machines

The merging of man and machine will not stop the rise of the machines

Tesla CEO and founder OpenAI Elon Musk last week suggested that humanity could nullify your fear of the rise of the machines (i.e. robots) due to the merger with these same machines and becoming cyborgs. However, modern trends in ...

The oldest discovered to date, the traces of life on Earth

The oldest discovered to date, the traces of life on Earth

the Origin of life on planet Earth is a very important subject for scientific research. Regular findings and discoveries constantly shift the moment the first living organism on and on . So this time canadian scientists discovered...

Can you live eating only one type of food?

Can you live eating only one type of food?

We are constantly told about the benefits of a varied diet. But if you had to survive on only one type of food — which one would leave you the longest life? Not by bread alone — at least because after a month of this experiment wi...

Some scholars categorically against the revival of extinct species

Some scholars categorically against the revival of extinct species

last month, the entire scientific community of the desire of Harvard scientists resurrect extinct species of animals. George Church from Harvard University, studying extinct species, said that in the coming years is going to resur...

In plants raised electrical circuit

In plants raised electrical circuit

Plants nourish life on Earth. They represent the original source of food, supplying energy to almost all living organisms and are the basis of fossil fuels, which feed the energy needs of the modern world. But the burning of long-...

Created flexible fibers conducting impulses to the brain and back

Created flexible fibers conducting impulses to the brain and back

according to the publication Medical Xpress, a large group of researchers, including engineers, chemists and neuroscientists, including many graduates of the Massachusetts Institute of technology (MIT) introduced a flexible fiber ...

Tomsk scientists have created a tiny, powerful particle accelerator

Tomsk scientists have created a tiny, powerful particle accelerator

Recently we wrote about the fact that on the basis of Tomsk Polytechnic University (TPU) made from the walls of the same educational institutions came not less interesting news. The specialists of TPU managed to develop a miniatur...

If atoms are mostly empty, why things are firm to the touch and in appearance?

If atoms are mostly empty, why things are firm to the touch and in appearance?

Chemist John Dalton proposed the theory that all matter and objects are made up of particles — atoms, and this theory is still accepted by the scientific community, after two hundred years. Each of these atoms consists of an extre...

Using neural network was able to simulate the behavior of complex quantum systems

Using neural network was able to simulate the behavior of complex quantum systems

the Modeling of complex organized quantum systems on today — an extremely difficult task. The fact that the traditional methods are not suitable here, since with increasing system complexity the number of States increases ex...

Which end is waiting for the Solar system?

Which end is waiting for the Solar system?

it took 13.8 billion years of cosmic evolution, so we ended up here. Generation of stars had to live and die to create heavy elements; tiny protogalaxies had to merge to form the milky Way; clouds of interstellar gas were to colla...