New drug to fight superbugs as "a Trojan horse"

Date:

2018-10-30 17:15:06

Views:

3380

Rating:

1Like 0Dislike

Share:

New drug to fight superbugs as Source:

In recent years, the number of superbugs (in other words, bacteria resistant to almost all known antibiotics) are becoming more and more. And this is in fact a real problem that need to do something. The obvious conclusion — to develop a "superactivity". But there is another method, which the authors call a "Trojan horse in the fight against superbugs".

As the publication of the New Atlas, a new drug called refigerator and at the moment he is already undergoing clinical trials. Moreover, the action of the drug rather elegant way. The main mechanism of action is based on the fact that many superbugs need for iron to sustain life processes. It is this vulnerability of the drug and "uses"

"Refigerator uses a new mechanism of penetration into the cell. It binds with the iron, penetrates with him inside the bacteria and destroys it from the inside." — said lead author of the project Simon Portsmouth.

This drug has successfully completed phase three trials, the last of which was with the participation of 448 patients with complicated urinary tract infections. Efficacy compared with a combination of antibiotics imipenem and cilastatin. It turned out that refigerator not only not inferior to the combination of drugs, but also causes much less side effects.

"the results are extremely important, because at the moment we have in the Arsenal, very few drugs against superbugs. As we found out, now refigerator has the highest effectiveness against gram-negative microorganisms."

If the results are confirmed by further tests — he'll get approval from Management on sanitary inspection behind quality of foodstuff and medicines USA (FDA), and therefore the output of the drug on the market will be held in the near future.

Recommended

Can genes create the perfect diet for you?

Can genes create the perfect diet for you?

Diet on genotype can be a way out for many, but it still has a lot of questions Don't know what to do to lose weight? DNA tests promise to help you with this. They will be able to develop the most individual diet, because for this they will use the m...

How many extraterrestrial civilizations can exist nearby?

How many extraterrestrial civilizations can exist nearby?

If aliens exist, why don't we "hear" them? In the 12th episode of Cosmos, which aired on December 14, 1980, co-author and host Carl Sagan introduced viewers to the same equation of astronomer Frank Drake. Using it, he calculated the potential number ...

Why does the most poisonous plant in the world cause severe pain?

Why does the most poisonous plant in the world cause severe pain?

The pain caused to humans by the Gimpi-gympie plant can drive him crazy Many people consider Australia a very dangerous place full of poisonous creatures. And this is a perfectly correct idea, because this continent literally wants to kill everyone w...

Comments (0)

This article has no comment, be the first!

Add comment

Related News

CRISPR opens the way for a new method of treatment —

CRISPR opens the way for a new method of treatment — "genomic surgery"

the Notorious editor of the CRISPR-Cas9 was a breakthrough in genetics. With his help I made a few discoveries. It also marked the beginning of the phenomenon of "gene therapy". However, the group of doctors from the University of...

Discovered structure, with a large regenerative potential than stem cells

Discovered structure, with a large regenerative potential than stem cells

Stem cells have long (and very successfully) used in the so-called regenerative medicine. However, as it turned out, there is in our body and better structures that will give a new impetus to the development of new technologies fo...

NASA tested a parachute for landing on Mars

NASA tested a parachute for landing on Mars

At the moment the American space Agency NASA have been preparing for the Mars 2020 mission. Through the planned series of tests recently completed the third (and final) stage of testing of the parachute system ASPIRE (Advanced Sup...

T. rex bite with incredible force: two times stronger than any living creature

T. rex bite with incredible force: two times stronger than any living creature

a Deadly combination of a powerful bite, strong teeth and chewing was allowed a giant bird of prey, T. rex — to literally break the bones of their victims, scientists have found. Bones have nutritional internal cavity filled with ...

A strange cloud on Mars was water vapor, not eruption

A strange cloud on Mars was water vapor, not eruption

the day before Yesterday about the strange cloud that appeared above the surface of the red planet, reminiscent of a train. The mysterious photo was published by the European space Agency, it took the Orbiter Mars Express. The tra...

Scientists from Stanford have figured out how to get from carbon dioxide in the hydrocarbon fuel

Scientists from Stanford have figured out how to get from carbon dioxide in the hydrocarbon fuel

Emissions of carbon dioxide in the atmosphere over the last several decades has greatly crippled the ecology of our planet. That is why more and more developments in the field of creation of means to reduce carbon dioxide emission...

The feature of the surface of the asteroid Ryugu jeopardizes the mission, the Japanese probe

The feature of the surface of the asteroid Ryugu jeopardizes the mission, the Japanese probe

Discovered a feature of the surface of the asteroid Ryugu casts doubt on success of mission of the Japanese space probe "Hayabusa-2", whose main purpose is to collect samples of soil. We have previously reported that the surface o...

On the surface of one of Saturn's moons, scientists have discovered a strange divorce

On the surface of one of Saturn's moons, scientists have discovered a strange divorce

Analyzing data gathered by the space probe Cassini space Agency NASA, whose mission staggeringly , the scientists discovered a very interesting detail associated with Dione, the natural satellite of the gas giant Saturn. It turns ...

Why we need to stop confusing human and machine intelligence

Why we need to stop confusing human and machine intelligence

We are already accustomed to hearing phrases such as "machine learning" and "artificial intelligence". We think that someone was able to reproduce a human mind inside a computer. This, of course, not true. But part of the reason w...

Tiny octopus-killers reminded about the contamination of oceans

Tiny octopus-killers reminded about the contamination of oceans

there are a huge number of living creatures of different sizes and types. Scientists are constantly studying them and often make unexpected discoveries. For example, in February 2018, they learned that sea stars living in oceans, ...

Ginkgo Bioworks wants to turn the human cell into a

Ginkgo Bioworks wants to turn the human cell into a "factory on demand"

For the production of medicines and various products of the chemical and pharmaceutical industries today use huge factories, where hundreds of chemical reactions to create the desired ingredients. But it has long been known that o...

Scientists observe a strange cloud on Mars

Scientists observe a strange cloud on Mars

for more than a month, the spacecraft of the European space Agency observes a strange cloud-like plume located above the surface of the red planet. Scientists say that the location of the cloud does not change from 13 September – ...

A new modification of the CRISPR can edit up to 50 percent of the genome

A new modification of the CRISPR can edit up to 50 percent of the genome

Editor of CRISPR genome has become a very important tool in medical research and may ultimately have a significant impact on various areas: from agriculture to treat a whole heap of hereditary diseases. However, it is far from per...

Between string theorists dispute broke out: what if dark energy is not constant?

Between string theorists dispute broke out: what if dark energy is not constant?

Harvard physicist Qumran Vafa is one of the strongest supporters of string theory. But this summer, other theorists strings pounced on his last sentence, which may discredit their ideas, based on a decade of the assumption that th...

It turns out that the electron is almost perfectly round. What does this mean for physics?

It turns out that the electron is almost perfectly round. What does this mean for physics?

the Electrons are almost perfectly round. This is revealed in research published recently in the journal Nature. Why is it important? Because more flattened form could hint at the presence of invisible subatomic particles. And so,...

Astronomers have discovered the youngest pulsar in the milky Way

Astronomers have discovered the youngest pulsar in the milky Way

Using data obtained by x-ray space Observatory Chandra space Agency NASA, a group of American astronomers has confirmed the presence of the very young pulsar in our galaxy. The discovery may give researchers new data on the evolut...

An experimental

An experimental "cocktail" of known drugs extended the life of the living organism 2 times

In the field of anti-aging and creation of new methods of rejuvenation and prolongation of life, provided one is already a lot of experiments. But they are all associated with the development of something new (and therefore expens...

As the coat color of Labrador affects their life expectancy?

As the coat color of Labrador affects their life expectancy?

the Study, which was published in the journal Canine Genetics and Epidemiology, has shown that chocolate Labrador retrievers often experience health problems and die faster than dogs of the same breed, but with a different coat co...

Discovered the

Discovered the "switch" pleasure from alcohol

One of the key factors of addiction mechanisms in the brain is obtaining positive emotions. For example, the alcohol getting to the brain, affects the ventral tegmental area (ventral tegmental area, VTA), also called the pleasure ...

Ten predictions of Hawking, which he left in the book after his death

Ten predictions of Hawking, which he left in the book after his death

the Latest work of Stephen Hawking, which deals with such problems as the existence of God or the possibility of time travel, was presented on Monday his children who tried to finish the book after the death of the British giant o...