Scientists restore memory in Alzheimer's disease

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2018-10-08 16:00:06

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Scientists restore memory in Alzheimer's disease


One of the most unpleasant manifestations of Alzheimer's disease is the gradual loss of memory and memories, which radically changes the whole personality of a person. However, it is possible that soon we will be able to handle it. At least, according to reports, a group of experts from France and India were able in the course of a series of experiments to fully restore in laboratory animals with Alzheimer's long term memory and to restore severed neural connections in the brain.

Responsible For the development of a group of experts from the Department of molecular biology and genetics, Centre for policy research studies. Jawaharlal Nehru (JNCASR), headed by Professor Tapas Kundu. They managed to create a molecule that the brain activates 2 of the enzyme — acetyltransferase of histones, CBP and P300, which are responsible for the formation of neural connections.

"We wondered if the molecule might improve memory in healthy mice, then will she be able to recover lost memory in mice with Alzheimer's disease? We found a molecule that activates two enzymes in patients and mice produce new neurons. In addition, 81 gene, expression of which was suppressed in mice with Alzheimer's disease, was activated to a normal state. In addition to the full restoration of the lost memory, we studied and other symptoms of Alzheimer's disease." — said Professor Kundu in an interview with the Journal of Neuroscience.

Researchers believe that most clinical trials of Alzheimer's disease have failed from the fact that the memory disorder occurs in the later stages, when the brain is already affected with deposits of an abnormal protein and has a damaged neural connection. In the course of work, scientists have found a way to reverse the damage and restore neural connections.

"There is a likelihood that the molecule, at least can delay the development of cognitive dysfunction. In addition, in laboratory animals, we observed no development of signs of progressive brain damage. Currently, we are studying mice with Alzheimer's, which a year. And the first results are encouraging. Long-term memory in animals do not suffer."

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