The human immunodeficiency Virus (HIV) is considered «the plague of the XXI century». Despite significant advances in many areas of medicine and improving the quality of life in the fight against this insidious virus humanity is losing. While the idea of creating a vaccine does not leave the minds of researchers from all over the world. And according to an article published in the journal Nature, a group of molecular biologists succeeded thanks to the newly open to the antibodies triggers a powerful immune response to HIV strains in the body of the monkeys.
Two years ago, researchers led by Michael Nussenzweig from the Rockefeller University in new York opened an antibody 3BNC117, which is able to suppress the propagation of several species of human immunodeficiency virus and even marking them for destruction by the immune system. Antibody 3BNC117 was separated from the body of one HIV-infected patient, the immune system of which struggled with a viral infection. In addition, the researchers conducted a series of clinical tests on patients with HIV. During the experiments, the molecules 3BNC117 were not given the virus to multiply within 2 months after discontinuation of antiretroviral drugs.
In addition, there is another antibody that can be used for the acquisition of immunity to HIV — 10-1074. Team Michael Nussenzweig decided to try to combine these 2 products to create a vaccine against HIV. The subsequent series of tests were conducted on monkeys: 12 monkeys was infected with SHIV (a monkey version of HIV), and after 3 days in their bloodstream began to introduce high-dose 3BNC117 and 10-1074. Antibodies continued to suppress the virus for six months while their molecules were present in the bloodstream. Then the virus started to multiply. It would seem that scientists were able to create the next drug so-called maintenance therapy, but in the next 1.5 years has done something extraordinary. 9 out of 12 monkeys developed severe immune reaction to the virus, and the level of infection in the body is dramatically decreased and again increased, despite the fact that the closest relatives of the person not received treatment with antiretroviral drugs.
As the researchers say, this method of dealing with HIV may be applicable to people, and now experts aims to find out if it works the same way for monkeys who acquired HIV 6 weeks before the start of treatment, because approximately this time, a person passes between infection and detection of infection. As stated by Michael Nussenzweig
«Our therapy produces a powerful immune response to HIV and allow the body to control the infection. It works on the same principles as immunotherapy of cancer, using similar mechanisms that already exist in the immune system monkeys and humans».
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