AI improved editor of genome, predicting the results

Date:

2018-11-09 02:15:07

Views:

54

Rating:

1Like 0Dislike

Share:

AI improved editor of genome, predicting the results

With the editor of the genome of the CRISPR-Cas9 is pretty well learned to deal. However, with a fairly good knowledge of technology and how it works, the results obtained in the course of editing, not always predictable. This is due to the peculiarities of the editing process and that the outcome is learned to predict artificial intelligence, further improving the performance of the method for genome editing.

To start I would like to explain what is the main problem. Oddly enough, the editor of the genome there is almost nothing to do with it. The protein Cas9 in this case performs the function of the blade and cuts a required component of the genome. But next to "empty space" you need to insert another component. It uses matrix DNA, which, if explained in plain language, acts as a "donor" material. This process is called DNA repair. There are other systems that work on a similar principle in the absence of matrix DNA, but in them lies the problem: after the replacement of the genetic material may remain deletions (roughly speaking, missing plots). The outcome of these interventions is informed and can be computed only empirically.

According to the editors of the journal Nature, a team of scientists from the Massachusetts Institute of Technology (MIT) have developed a program based on artificial intelligence that calculates the result of changes in the genome. AI is able to tell what kind of sequence is formed in place of the intervention after editing, as well as at least 50% of the cases, according to whether after the operation to remain deletions. In addition, if you use AI to predict all stages, the prediction accuracy can be increased to 5-11%, which is a very good result.

In order to teach the AI to predict the outcome of the intervention in the genome, the scientists created a library of 2000 the guide RNA for Cas9 (namely RNA specifies protein where to cut the molecule). Next of them was selected as 14, which could after reparations cause the appearance of excess nucleotide, and then AI chose the ones that most often led to errors reparations. Based on these data was built "model behavior", which has already been used for other operations. Scientists have managed effectively and without any side effects edit of mutation in cells with the syndrome of the German-Pudlak and disease Menekse.

This and other news you can discuss in our

Recommended

Multi-dose capsule with the drug passed the first test on humans

Multi-dose capsule with the drug passed the first test on humans

as strange As it may sound, but violation of order of medications is a fairly common reason that drugs are not good enough or do not act at all and may cause side effects. For some drugs the frequency of administration can be vital and doctors and ph...

Scientists have created a unique implant that will not be rejected by the body

Scientists have created a unique implant that will not be rejected by the body

Any material (including biological), which are not created by our bodies in any event are foreign and will reject. And even if they are made of the most advanced inert material, ensure that rejection will not happen, nobody will. And "suppress" the i...

Scientists create laser dermal regenerator from the

Scientists create laser dermal regenerator from the "star trek"

Technology from a sci-Fi universe of "star trek" continues to penetrate into our real life. We have already read about the medical tricorder, heard about the development of the warp engine, been evaluated by food printers. Now it's time for a "skin r...

Comments (0)

This article has no comment, be the first!

Add comment

Related News

Nanorobots to treat diseases was first introduced in the human eye

Nanorobots to treat diseases was first introduced in the human eye

researchers from the Institute for intelligent systems max Planck in Stuttgart is now one step closer to creating microbots for the treatment of various diseases. At the moment, they have already successfully tested a miniature ro...

Fish rich diet will help in the fight against asthma

Fish rich diet will help in the fight against asthma

a Clinical study conducted by the University of La Trobe, showed that eating fish — salmon, trout and sardines — as part of a healthful diet may reduce asthma symptoms in children. During the international study found that childre...

Genetic factors of obesity protects against diabetes

Genetic factors of obesity protects against diabetes

Some genetic variations associated with obesity, may protect against type 2 diabetes, heart attack and stroke, scientists say. They believe that it places on the body where the body stores fat on the abdomen or around the liver ma...